Birth Defects Res B Dev.Reprod.Toxicol. 4-26-2011;135(1):179-185. 2007;42(10):1074-1077. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. Konoshima, T., Kokumai, M., Kozuka, M., Iinuma, M., Mizuno, M., Tanaka, T., Tokuda, H., Nishino, H., and Iwashima, A. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others. Metformin (Glucophage) is used to help decrease blood sugar. Am J Chin Med 2008;36(3):517-540. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. Z., Bai, L., Chen, D. G., Xu, Q. T., and Southerland, W. M. Computational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder. A., and Provalova, N. V. [The modulating effects of preparations of Baikal skullcap (Scutellaria baicalensis) on erythron reactions under conditions of neurotic exposures]. Statements made about products have not been evaluated by the Food and Drug Administration. Zhong.Yao Cai. View abstract. Baikal skullcap might decrease blood sugar. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. View abstract. Blach-Olszewska, Z., Jatczak, B., Rak, A., Lorenc, M., Gulanowski, B., Drobna, A., and Lamer-Zarawska, E. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. View abstract. Baikal skullcap might change the levels of statins in your blood. Baikal skullcap might lower blood pressure. View abstract. Clin Transl Sci 2021;14(5):2017-2024. 1989;35(3):331-335. Tseng-Crank J, Sung S, Jia Q, and et al. In Vivo 2004;18(4):497-503. J Interferon Cytokine Res 2008;28(9):571-581. J Ethnopharmacol. View abstract. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. CAS #:94279-99-9 | EC #:304-845-9. Chem Pharm Bull (Tokyo) 1992;40(2):531-533. Phytother.Res 2003;17(6):640-644. View abstract. Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others. Beijing Da.Xue.Xue.Bao. 73.^ Hwang YK, Jinhua M, Choi BR, Cui CA, Jeon WK, Kim H, Kim HY, Han SH, Han JS Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion View abstract. Accessed Sept 30, 2016. Available at: https://www.fda.gov/food/alerts-advisories-safety-information/fda-alerts-consumers-about-potentially-life-threatening-health-problems-linked-limbrel. View abstract. Comparison of anti-inflammatory and anti-nociceptive activities of Curcuma wenyujin Y.H. View abstract. Biomed.Chromatogr. Ready to start planning your care? Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Toxicology 5-2-2009;259(1-2):10-17. Further research is needed to confirm these effects. Zhang H, Huang J. View abstract. The root is used to make medicine. View abstract. There have been reports of fever and lung inflammation in people who took Baikal skullcap. Lin, A. M., Ping, Y. H., Chang, G. F., Wang, J. Y., Chiu, J. H., Kuo, C. D., and Chi, C. W. Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain. View abstract. View abstract. View abstract. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. View abstract. Yoo, H. H., Park, J. H., and Kwon, S. W. In vitro cytotoxic activity of some Korean medicinal plants on human cancer cell lines: enhancement in cytotoxicity by heat processing. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. Taking Baikal skullcap along with medications that lower blood pressure might cause blood pressure to go too low. View abstract. The total content of these 6 main flavonoids account ed for 68.5% of the extract . View abstract. Scutellaria baicalensis is a very well-known anti Zhang H and Huang J. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. View abstract. The resemblance of its flower to medieval helmets is the reason behind its name skullcap. Study on the effects of extracts from Scutellaria baicalensis combined with cisplatin on apoptosis of human ovarian carcinoma cell line SKOV-3. Regulatory effects of gibberellic acid (GA3) on shoot and root formation of Huang-qin (Scutellaria baicalensis) in vitro. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Talk with your healthcare provider before using this product if you are taking lithium. Planta Med 2006;72(14):1318-1321. Zhang, S., Jin, Y., Zhu, W., Tang, J., Hu, S., Zhou, T., and Chen, X. Baicalin released from Scutellaria baicalensis induces autotoxicity and promotes soilborn pathogens. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Consult your Doctor if you are Pregnant and Breastfeeding. If you take it, consider monitoring your blood sugar level regularly and pay proper attention to the amount of Baikal skullcap. Planta Med 1998;64:571-2. OTHER NAME(S): Baicalein, Baikal Scullcap, Baikal Skullcap Root. Blood 2-15-2008;111(4):2354-2363. Biochim Biophys Acta 1999;1472:643-50. J Dermatol Sci 2007;46(1):31-40. Watanabe S, Kitade Y, Maski T, Nishioba Planta Med 2000;66(8):694-698. Anesth Analg 2003;97:1724-9. View abstract. View abstract. Zhongguo Ying.Yong.Sheng Li Xue.Za Zhi 2009;25(3):344-348. Puri BK, White N, Monro JA. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. View abstract. Altavilla D, Squadrito F, Bitto A, et al. Liao JF, Wang HH, Chen MC, et al. View abstract. Neo-clerodane diterpenoids also have demonstrated anticancer(24) and antiviral(25) activities. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. Nutr Res 2009;29:298-304. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. Zhang CZ, Wang SX, Zhang Y, et al. What Are The Several Uses Of This Medicinal Herb? It is also used as a diuretic, and should not be confused with Scutellaria baicalensis. Shang, Y. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. View abstract. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. Efficacy of Scutellaria baicalensis for the treatment of hand, foot, and mouth disease associated with encephalitis in patients infected with EV71: a multicenter, retrospective analysis. Gao, Z., Huang, K., and Xu, H. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. A proprietary aqueous S. barbata extract appears to target tumor mitochondria to induce ROS generation and DNA damage followed by PARP hyperactivation, cellular ATP and NAD depletion, and glycolysis inhibition(33). Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Information from this source is evidence-based and objective, and without commercial influence. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Chen C, Mireles RJ, Campbell SD, et al. Li L, Gao H, Lou K, et al. View abstract. 5. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Lee, Y. M., Cheng, P. Y., Chim, L. S., Kung, C. W., Ka, S. M., Chung, M. T., and Sheu, J. R. Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. With cancer, where you get treated first matters. Scutellaria baicalensis | Memorial Sloan Kettering Cancer Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. 4-12-2011;134(3):884-891. Baikal skullcap might lower blood sugar levels. J Ethnopharmacol 2005;98:295-300. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Food Chem . Treatment of acute bronchiolitis with Chinese herbs. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. 11-1-2009;284(2):198-207. 2004;23(8):874-878. View abstract. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. 2010;16(2):32-40. 4-12-2011;134(3):884-891. But there is not enough information to know if Baikal skullcap is the cause of these side effects. J Ethnopharmacol. View abstract. Planta Med 2000;66:91-3. J Cell Biochem 10-1-2010;111(2):274-283. However, both S. baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects . View abstract. Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. 9-7-2009;125(2):286-290. It's one of the most commonly used thickeners and emulsion stabilizers.If the product is too runny, a little xanthan gum will make it more gel-like. Scutellaria baicalensis root is a plant/plant extract used in some OTC (over-the-counter) products. View abstract. This is especially relevant to macrophages and immune cells. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. It might cause drowsiness. 1997;57(1):63-67. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. 1-19-2007;109(2):325-330. Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. View abstract. Allergic contact dermatitis to Tinosorb S, Scutellaria baicalensis, and other emerging allergens in cosmetics. View abstract. View abstract. Laboratory studies have shown S. barbata can limit the growth of cancer cells. Statements made about products have not been evaluated by the Food and Drug Administration. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. Elevated high-sensitivity C-reactive protein and high triglycerides were possibly related to ingestion of baicalein tablets in healthy subjects and should be monitored in future studies(25). View abstract. View abstract. View abstract. In addition, it can reduce inflammation in the body can easily heal liver toxicity, and can detoxify the body. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Kim M, Lee BC. Ren S, Cao D., Yang J, and et al. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. J Cell Biochem 12-15-2010;111(6):1629-1641. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. Zhang, K., Guo, Q. L., You, Q. D., Yang, Y., Zhang, H. W., Yang, L., Gu, H. Y., Qi, Q., Tan, Z., and Wang, X. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. View abstract. View abstract. WebScutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. View abstract. Chung Hsi I Chieh Ho Tsa Chih 1990;10:278-9, 260. It is used with other herbs in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. Toxicology 3-4-2009;257(1-2):80-85. Cancer Lett. Hirunuma, M., Shoyama, Y., Sasaki, K., Sakamoto, S., Taura, F., Shoyama, Y., Tanaka, H., and Morimoto, S. Flavone-catalyzed apoptosis in Scutellaria baicalensis. View abstract. View abstract. 2020 Apr;82(4):253-254. Shang, Y. Baikal skullcap might cause sleepiness and slowed breathing. Takeshita K, Saisho Y, Kitamura K, et al. 2005 - 2023 WebMD LLC, an Internet Brands company. Biochem Biophys Res Commun 9-24-2000;276(2):534-538. Journal of medicinal food 2009;12(5):1143-8. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Some medications are changed and broken down by the liver. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Cheng, K. T., Huang, Y. C., Lin, Y. S., Su, B., and Chen, C. M. Effects of baicalin on the gene expression of surfactant protein A (SP-A) in lung adenocarcinoma cell line H441. Eksp Klin Farmakol 1997;60:28-30. Chung, C. P., Park, J. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Most studies have been done in the lab rather than in humans, and suggest anti-inflammatory and antioxidant activity. 1-27-2011;133(2):634-641. View abstract. Baikal skullcap might change how these pumps work and change how much medication stays in the body. There are a number of different names that people use for Baicalin. Razina, T. G., Udintsev, S. N., Tiutrin, I. I., Borovskaia, T. G., and Iaremenko, K. V. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap]. Cancer Lett. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Some medications, called sedatives, can also cause sleepiness and slowed breathing. View abstract. Morgan SL, Baggott JE, Moreland L, et al. Kowalczyk, E., Krzesinski, P., Kura, M., Niedworok, J., Kowalski, J., and Blaszczyk, J. Sasaki, K., Taura, F., Shoyama, Y., and Morimoto, S. Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis georgi. View abstract. S. barbata possesses a range of antitumor activities via multiple intracellular targets(20), with major anticancer constituents identified as scutellarin, apigenin5-O--glucopyranoside, apigenin, p-coumaric acid, luteolin and 4-hydroxywogonin(22). Cancer Lett. View abstract. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. This could change the effects and side effects of these medications. To avoid any unwanted skin irritation you should consult with a doctor, dermatologist or trained professional before applying the ingredient onto the skin. Planta Med 2000;66:70-1. View abstract. View abstract. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of. Scutellaria baicalensis Georgi extracts inhibit RANKL-induced osteoclast differentiation. This side effect does not appear to be common and might only occur in people who have a type of allergic reaction to it. Liao, H. L. and Hu, M. K. Synthesis and anticancer activities of 5,6,7-trimethylbaicalein derivatives. View abstract. View abstract. Li, H. N., Nie, F. F., Liu, W., Dai, Q. S., Lu, N., Qi, Q., Li, Z. Y., You, Q. D., and Guo, Q. L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. Che, Q. M., Huang, X. L., Li, Y. M., Kun, Z., Teruaki, A., and Masao, H. [Studies on metabolites of baicalin in human urine]. Analysis of essential oils from different organs of Scutellaria baicalensis. View abstract. 4 Physical and Chemicals Properties Scutellaria Baicalensis Root Extract In an ultraviolet (UV) spectral analysis of a Scutellaria baicalensis root extract (aqueous ethanol extract), an absorption peak between 200 and 250 nm and an absorption peak between 250 and 300 nm were Pharmacol.Res. View abstract. Lee BH, Lee SJ, Kang TH, et al. Pharmacogenomics of human OATP transporters. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. Yuan Y., Liu Y.J, Luo Y.J, and et al. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. 2009;30(11):1505-1512. Front Biosci. Cancer Lett. J Ethnopharmacol. View abstract. View abstract. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. View abstract. View abstract. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. FDA Alerts Consumers About Potentially Life-Threatening Health Problems Linked to Limbrel. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. It can cause drowsiness, fever, lung inflammation, and other information-related issues. However, different extraction methodologies and/or plant origins have yielded varying degrees of antitumor effects(21). Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. 2004;91(1):65-68. WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. View abstract. View abstract. Phytomedicine. Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors. Use of this Web site does not create an expressed or implied physician-patient relationship. View abstract. Eksp Klin Farmakol 1997;60:49-51. These include the Chinese Skullcap, Huang Qin, Scutellaria baicalensis (the scientific name), and the Hooded Willow Herb. In this article, we explore the top Baicalin benefits that you can experience today. Your lithium dose might need to be changed. CAS #:94279-99-9 | EC #:304-845-9. CNS.Neurol.Disord Drug Targets. This could increase how much lithium is in the body and result in serious side effects. Baikal skullcap (scientific name Scutellaria baicalensis) is a plant. View abstract. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. Comparison of anti-inflammatory and anti-nociceptive activities of Curcuma wenyujin Y.H. Taking Baikal skullcap might decrease how well the body gets rid of lithium. 2000;23(5):272-274. Planta Med 2002;68(2):128-132. View abstract. 1-29-2010;469(3):298-302. Talk with your healthcare provider before using Baikal skullcap if you are taking medications used for lowering cholesterol. International Journal of Pharmacology 2010;6(2):81-88. reduce wrinkles, smooth skin) but without the side effects (though it seems now that the INCI name of Lanablue was Eksp Klin Farmakol 1997;60:28-30. View abstract. View abstract. Clin Pharmacol Ther 2007;82:726-33. 1998;61(2):54-56. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). Type of allergic reaction to it the Several Uses of this Web is... Can reduce inflammation in the body can easily heal liver toxicity, and the Hooded Willow Herb body easily. Scutellaria baicalensis, lamiaceae pay proper attention to the amount of Baikal skullcap in people took! Care and research S. baicalensis root and its main flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines ;. 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